Hypertrophy, Maximize gains -Unlock the Science of Building Muscle

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Introduction

Socrates, the OG of philosophy and Hypertrophy once said “No man has the right to be an amateur in the matter of physical training. It is a shame for a man to grow old without seeing the beauty and strength of which his body is capable.” I guess even back in 400 BC they knew the value of building muscle. Socrates – the original gym bro!

So what is Hypertrophy, it’s basically a fancy word for making gains! Its when your muscle increases in size which can be achieved by stuffing them with some extra muscle glycogen or by increasing the size and/or multiplying muscle fibres (AKA myofibrils).  So the question is how do we achieve this awe-inspiring feat to set us on our journey of becoming a Greek God!

Firstly lets have a look at the different types of training available;

TrainingStrength trainingSpeed trainingPower trainingEndurance trainingHypertrophy
FunctionLift heavier stuffMove an object from A to B as fast as possibleStrength + Speed = PowerMoving for as long as possibleIncrease muscle mass
Table 1: Different types of training

So does this mean that hypertrophy is not going to make us stronger?

Well there is a crossover between hypertrophy training and strength training. For instance Chris Bumstead is still strong AF, but Eddie Hall would definitely give him a run for his money on raw strength.

Hypertrophy Science Behind The Gains

Now, lets ditch the bro-science and look at the cold, hard facts-

Sets- A study by Krieger. (2010) found that performing a mere 2-3 sets per exercise per week produced a massive 40% more muscle compared to just one set, over a 24 week period. True bang for your buck! Schoenfeld et al. (2017a) had similar results, However, they also observed that at least 10 weekly sets per muscle group maximized increased muscle mass.

Reps –  Schoenfeld et al. (2021) played around with the amount of reps and found that training within the rep range of 8-12 produced significant changes in lean body mass compared to lower or higher reps. So if Greek God is the aim don’t bother with one-rep wonders or endless rep marathons.

Repetition Durations –  Slow and steady might win the race, but it wont give you those gains. Schoenfeld et al. (2015) observed that training within Repetition Durations of 0.5 to 8 seconds produced the best hypertrophy results. Reducing the rep duration to 10 seconds of more was not swole-worthy.

Intensity – lightweight baby is actually the path to gains. Schoenfeld et al. (2016a) observed that low loads below 60% 1 rep max achieved similar hypertrophy effects as high loads greater than 65% 1 rep max, at least in untrained individuals.  Schoenfeld et al. (2017) observed similar hypertrophy changes after the use of high or low loads but only when muscle failure was reached. So, its time to stop this ego lifting culture.

Frequency – Schoenfeld et al. (2019) investigated frequency and has put gains on a whole new wavelength. When volume is the same it really doesn’t matter if you spread your sets over 1 day or 3 days from a hypertrophy point. So its up to you if you dial your frequency up or down, just listen to your body people, and avoid overtraining.

Blood Flow Restriction – Just like the old saying ‘ tighten the gains by restricting the circulation’? This is something I have never tried and always seemed a bit crazy, you basically put a band around a limb to restrict blood flow  allowing you to train at a high intensity with a lower weight. The science is there though. Lixandrão et al. (2018) and Slysz et al.(2016) both show that when you restrict the flow and use low loads you will experience similar gains to higher loads.  But use these bands wisely you don’t want to turn your limbs into fancy sausages.

The Greek God Formula

So, what’s the magical hypertrophy formula to begin our Odyssey to become a Greek God? Aim for 10 sets per muscle group per week, play around within the 8-12 rep range and remember that slow and steady wins the race, but not too slow, keep reps under 10 seconds.

By implicating this you still need to ‘train hard or go home’ train close to muscle failure. Progressive overload should be used to ensure you are putting the required work in. Now remember that any training plan should be as unique as a fingerprint, based on your injuries, available equipment, time constraints and let’s be honest, how much you like or dislike an exercise. So have a peak at the below 3 day split. More experienced lifters will require additional volume, if you want a personalised programme get in touch here.

Day 1SetsDay 2SetsDay 3 Sets
Bench Press2Incline Bench Press2Decline Bench Press2
Dumbbell Flyes2Push-Ups2Cable Flyes2
Shoulder Press 2Shoulder Press2Arnold Press2
Lateral Raises2Front Raises2Lateral Raises2
Bicep Curls3Barbell Curls3Hammer Curls3
Tricep Dips3Tricep Rope Pushdowns3Overhead Tricep Extension3
Squats2Deadlifts2Lunges2
Leg Press2Leg Curls2Leg Extensions2
Lat Pulldowns2Pull-Ups2Chin-Ups2
Bent-Over Rows2Seated Cable Rows2Dumbbell Rows2
Hanging Leg Raises2Leg Raises2Plank2
Russian Twists2Bicycle Crunches2Reverse Crunches2
Table 2: Three day hypertrophy training split

Strength Vs Hypertrophy

Now lets address the elephant in the gym, strength vs hypertrophy. These are two different things, that’s not to say that you wont build strength with hypertrophy training or muscle with strength training, but for now strength deserves its own Odyssey. But to avoid any confusion  check out the quick cheat sheet below

 Hypertrophy TrainingStrength Training
IntensityUnder 85% 1RMAbove 85% 1RM
Reps8 to 121 to 5
Sets3 to 103 to 10
RestUnder 2 minsOver 2 mins
Table 3: Hypertrophy vs Strength

Hypertrophy benefits

Training for hypertrophy is not all about making gains and posing in front of a mirror, there are many benefits to the training;

  1. Wrapping your skeleton in muscle is the best way to increase longevity, as you get older muscle declines so it’s in your best interest to build muscle and hang onto it as you age.
  2. Strength gains, I know! Hypertrophy training is not the same as strength. Nevertheless you will make strength gains
  3. Improved metabolism meaning that you will burn more calories at rest
  4. Aesthetics: as much as you might not want to admit it, you want this!
  5. Injury prevention: Bigger stronger body will prevent injuries and clumsy mishaps will be reduced
  6. Increased bone density giving you stronger more resilient bones of steel!
  7. Hormonal response: Hypertrophy training will increase the release of Growth Hormone and Testosterone, which will give you more energy and make you feel generally better.
  8. Long term benefits: Your heart will be thankful, your blood sugar will be thankful and the future you will be thankful.

In a Nutshell

To sum up, training for hypertrophy can lead you to Greek Godliness and even just a few sets per week can do wonders, however for jaw-dropping gains you should aim for 10 sets per muscle group. Don’t forget, its all about quality 8-12 reps, slow and steady wins the race, but not too slow. And  don’t be afraid to go lightweight baby!

References

Krieger, J. W. (2010). Single vs. multiple sets of resistance exercise for muscle hypertrophy: a meta-analysis. J. Strength Cond. Res. 24, 1150–1159. https://journals.lww.com/nsca-jscr/Fulltext/2010/04000/Single_vs__Multiple_Sets_of_Resistance_Exercise.36.asp

Schoenfeld, B. J., Ogborn, D., and Krieger, J. W. (2015). Effect of repetition duration during resistance training on muscle hypertrophy: a systematic review and meta-analysis. Sports Med.  45, 577–585. https://link.springer.com/article/10.1007/s40279-015-0304-0

Schoenfeld, B. J., Wilson, J. M., Lowery, R. P., and Krieger, J. W.(2016a). Muscular adaptations in low- versus high-load resistance training: A meta-analysis. Eur. J. Sport Sci. 16, 1–10. https://www.tandfonline.com/doi/full/10.1080/17461391.2014.989922

Slysz, J., Stultz, J., and Burr, J. F. (2016). The efficacy of blood flow restricted exercise: a systematic review & meta-analysis. J. Sci. Med. Sport. 19, 669–675. https://www.jsams.org/article/S1440-2440(15)00182-6/fulltext

Schoenfeld, B. J., Grgic, J., Ogborn, D., and Krieger, J. W. (2017). Strength and hypertrophy adaptations between low- vs. high-load resistance training: a systematic review and meta-analysis. J. Strength Cond. Res . 31, 3508–3523. https://journals.lww.com/nsca-jscr/Fulltext/2017/12000/Strength_and_Hypertrophy_Adaptations_Between_Low_.31.aspx

Schoenfeld, B. J., Ogborn, D., and Krieger, J. W. (2017a). Dose-response relationship between weekly resistance training volume and increases in muscle mass: a systematic review and meta-analysis.J. Sports Sci. 35, 1073–1082. https://www.tandfonline.com/doi/full/10.1080/02640414.2016.1210197

Schoenfeld, B. J., Grgic, J., and Krieger, J. (2019). How many times per week should a muscle be trained to maximize muscle hypertrophy? A systematic review and meta-analysis of studies examining the effects of resistance training frequency. J. Sports Sci. 37, 1286–1295.  https://www.tandfonline.com/doi/full/10.1080/02640414.2018.1555906

Schoenfeld, B. J., Grgic, J., Every, D. W. V., and Plotkin, D.L. (2021) Loading Recommendations for Muscle Strength, Hypertrophy, and Local Endurance: A Re-Examination of the Repetition Continuum. Sports (Basel). 32. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927075/

Bernardez-Vazquez, R., Raya-Gonzalez, J., Castillo, D and Beato, M, (2022) Resistance Training Variables for Optimization of Muscle Hypertrophy: An Umbrella Review. Sports Act. 4. https://www.frontiersin.org/articles/10.3389/fspor.2022.949021/full